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MONDAY, Sept. 28, 2020 (HealthDay News) — Intrauterine exposure to maternal gestational diabetes is associated with an increased cardiovascular disease risk and risk factors in offspring up to age 35 years, according to a study published online Sept. 28 in CMAJ<\/i>, the journal of the Canadian Medical Association.<\/p>\n
Laetitia Guillemette, Ph.D., from the Children’s Hospital Research Institute of Manitoba in Winnipeg, Canada, and colleagues conducted a cohort study of 293,546 offspring born between 1979 and 2005 and followed until March 2015 to examine the potential association between exposure to maternal diabetes and cardiovascular disease events.<\/p>\n
The researchers found that during 3,628,576 person-years of follow-up, 0.9 percent of the offspring experienced a cardiovascular disease end point and 4.3 percent experienced a cardiovascular disease risk factor. The risk for cardiovascular disease end points was significantly increased in offspring exposed to gestational diabetes after propensity score matching (adjusted hazard ratio, 1.42; 95 percent confidence interval, 1.12 to 1.79); no significantly increased risk was seen with exposure to type 2 diabetes (adjusted hazard ratio, 1.40; 95 percent confidence interval, 0.98 to 2.01). For cardiovascular disease risk factors, a similar association was observed (gestational diabetes: adjusted hazard ratio, 1.92; 95 percent confidence interval, 1.75 to 2.11; type 2 diabetes: adjusted hazard ratio, 3.40; 95 percent confidence interval, 3.00 to 3.85).<\/p>\n
“Screening children with in utero exposure to diabetes for cardiovascular disease risk factors might help to evaluate the future burden related to cardiovascular disease in the population,” the authors write.<\/p>\n