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THURSDAY, Oct. 1, 2020 (HealthDay News) — Alcoholic formulations of chlorhexidine gluconate (CHG) seem to be safe and effective in preventing surgical site infections in clean surgery, according to a review published online Sept. 1 in the Annals of Surgery<\/i>.<\/p>\n
Ryckie G. Wade, from the University of Leeds in the United Kingdom, and colleagues conducted a systematic literature review and network meta-analysis to evaluate the efficacy of CHG- and povidone-iodine (PVI)-based skin antiseptics for preventing surgical site infections in adults undergoing clean surgery.<\/p>\n
Based on 17 studies comparing five antiseptics in 14,593 individuals, the researchers found that the overall rate of surgical site infection was 3 percent. The most effective antiseptic was alcoholic CHG 4 to 5 percent, which halved the risk for surgical site infection versus aqueous PVI (relative risk [RR], 0.49; 95 percent confidence interval [CI], 0.24 to 1.02) and alcoholic PVI (RR, 0.51; 95 percent CI, 0.21 to 1.27). Only patients exposed to PVI experienced adverse events related to antiseptic application.<\/p>\n
“Our findings concur with the literature on contaminated and clean-contaminated surgery, and endorse guidelines worldwide which advocate the use of alcoholic CHG for preoperative skin antisepsis,” the authors write.<\/p>\n
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