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WEDNESDAY, Oct. 21, 2020 (HealthDay News) — Exposure to maternal hypothyroidism during the periconceptual period is associated with an increased risk for childhood attention-deficit hyperactivity disorder (ADHD) in offspring, according to a study published online Oct. 21 in the American Journal of Perinatology<\/i>.<\/p>\n
Morgan R. Peltier, Ph.D., from the NYU-Long Island School of Medicine in Mineola, New York, and colleagues abstracted data from linked maternal-child medical records to examine the impact of maternal hypothyroidism prior to or during pregnancy on the risk for childhood ADHD.<\/p>\n
The researchers found that hypothyroidism diagnosed prior to or during pregnancy was associated with an increased risk for ADHD in children (adjusted hazard ratios [aHRs], 1.27 [95 percent confidence interval (CI), 1.15 to 1.41] and 1.17 [95 percent CI, 1.00 to 1.38], respectively). The association was strongest with diagnosis during the first trimester (aHR, 1.28; 95 percent CI, 1.04 to 1.58). A significantly increased risk for ADHD was seen for children born preterm if their mothers were diagnosed prior to, but not during, pregnancy (aHR, 1.43; 95 percent CI, 1.09 to 1.8). The impact of maternal hypothyroidism on increased ADHD risk was stronger for boys than girls (aHRs, 1.26 [95 percent CI, 1.14 to 1.40] and 1.19 [95 percent CI, 1.01 to 1.40], respectively) and for Hispanic children versus other race ethnicities (aHR, 1.45; 95 percent CI, 1.25 to 1.68).<\/p>\n
“Our findings make clear that thyroid health likely has a much larger role in fetal brain development and behavioral disorders like ADHD than we previously understood,” Peltier said in a statement.<\/p>\n
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