Increased risk compared with general population likely due to nulliparity among ART-treated women; risk not increased versus subfertile women<\/p>\n<\/h3>\n
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MONDAY, Nov. 30, 2020 (HealthDay News) — Women treated with assisted reproductive technology (ART) do not have an increased risk for ovarian cancer compared with subfertile women not receiving ART, according to a study published online Nov. 17 in the Journal of the National Cancer Institute<\/em>.<\/p>\n In an effort to examine ovarian tumor risk, Mandy Spaan, from the Netherlands Cancer Institute in Amsterdam, and colleagues conducted a cohort study involving 30,625 women who received ovarian stimulation for ART in 1983 to 2000 and 9,988 subfertile women not treated with ART.<\/p>\n The researchers identified 158 invasive and 100 borderline ovarian tumors after a median follow-up of 24 years. The risk for ovarian cancer was increased in the ART group compared with the general population (standardized incidence ratio [SIR], 1.43; 95 percent confidence interval [CI], 1.18 to 1.71), but not compared with the non-ART group (age- and parity-adjusted hazard ratio [HR], 1.02; 95 percent CI, 0.70 to 1.50). With higher parity and a larger number of successful ART cycles (resulting in childbirth), risk decreased, but there was no association noted for the number of unsuccessful cycles. ART-treated women had an increased risk for borderline ovarian tumors compared with the general population (SIR, 2.20; 95 percent CI, 1.66 to 2.86) and compared with non-ART-treated women (HR, 1.84; 95 percent CI, 1.08 to 3.14).<\/p>\n “The higher risk of ovarian cancer compared with the general population is likely due to the higher prevalence of nulliparity in ART-treated women,” the authors write.<\/p>\n