Remission rates greater in younger participants and those with short diabetes duration, higher HOMA percentage B<\/strong><\/p>\n<\/h3>\n <\/b><\/p>\n <\/b><\/p>\n WEDNESDAY, Dec. 9, 2020 (HealthDay News) — More than half of severely obese patients undergoing Roux-en-Y gastric bypass (RYGB) have diabetes remission, according to a study published online Dec. 3 in the Journal of Clinical Endocrinology & Metabolism<\/em>.<\/p>\n Jonathan Q. Purnell, M.D., from the Oregon Health & Science University in Portland, and colleagues compared diabetes prevalence and remission rates during seven years of follow-up after RYGB and laparoscopic gastric banding (LAGB) in an observational cohort of 2,256 adults with severe obesity at 10 U.S. hospitals.<\/p>\n The researchers found that diabetes remission occurred in 57 percent (46 percent complete; 11 percent partial) and in 22.5 percent (16.9 percent complete; 5.6 percent partial) after RYGB and LAGB, respectively. Remission was greater in younger participants and those with shorter diabetes duration, higher C-peptide levels, higher homeostatic model assessment (HOMA) percentage B (a measure of \u00c3\u009f-cell activity), and lower insulin usage at baseline and with greater postsurgical weight loss following both procedures. Reduced HOMA insulin resistance was associated with a greater likelihood of diabetes remission after LAGB, while after RYGB, increased HOMA percentage B predicted remission. Diabetes remission remained nearly fourfold higher for RYGB versus LAGB after controlling for weight lost.<\/p>\n “Our large study confirms the importance of weight loss on inducing diabetes remission, but also finds gastric bypass has benefits independent of weight,” Purnell said in a statement. “If we can understand what these benefits are, it could lead to new diabetes treatments.”<\/p>\n One author disclosed financial ties to a medical device company; a second author disclosed ties to a pharmaceutical company.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n