<\/u>Children with versus those without AKI have lower scores on tests of short-term memory during DKA<\/strong><\/p>\n<\/h3>\n <\/b><\/p>\n <\/b><\/p>\n MONDAY, Dec. 14, 2020 (HealthDay News) — For children with diabetic ketoacidosis (DKA), acute kidney injury (AKI) is common and is associated with cognitive issues, including lower scores on tests of short-term memory, according to a study published online Dec. 4 in JAMA Network Open.<\/em><\/em><\/p>\n Sage R. Myers, M.D., from the Children’s Hospital of Philadelphia, and colleagues examined risk factors for AKI and its association with neurocognitive outcomes in pediatric DKA. A total of 1,359 DKA episodes were included for children aged younger than 18 years; episodes with and without AKI were compared.<\/p>\n The researchers found that AKI occurred in 584 episodes (43 percent); 252 AKI events (43 percent) were stage 2 or 3. In multivariable analyses, variables associated with AKI included older age (adjusted odds ratio [AOR] per one year, 1.05), higher initial serum urea nitrogen (AOR per 1 mg\/dL increase, 1.14), higher heart rate (AOR per 1-standard deviation increase in z-score, 1.20), higher glucose-corrected sodium (AOR per 1 mEq\/L increase, 1.03), glucose concentrations (AOR per 100 mg\/dL increase, 1.19), and lower pH (AOR per 0.1 increase, 0.63). Compared to those without, children with AKI had lower scores on tests of short-term memory during DKA and lower mean IQ scores three to six months after recovery from DKA.<\/p>\n “More clearly defining the mechanisms of kidney injury resulting from DKA could have important implications for the development of new therapeutic and preventive strategies,” the authors write.<\/p>\n One author disclosed receiving fees from InsuCalc.<\/p>\n