Contrary to current evidence, moderate\/vigorous activity may increase risk<\/p>\n<\/h3>\n
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WEDNESDAY, Dec. 16, 2020 (HealthDay News) — Physical activity (PA) might not protect against schizophrenia risk, according to a research letter published online Dec. 9 in JAMA Psychiatry<\/em>.<\/p>\n Sergi Papiol, Ph.D., from the University Hospital in Munich, Germany, and colleagues examined the association between PA and schizophrenia risk using data from the U.K. Biobank.<\/p>\n The researchers observed no association between PA and schizophrenia risk in any analyses. There was evidence of an association between self-reported moderate\/vigorous PA and increased schizophrenia risk in a univariate analysis with and without correction for body mass index (BMI). A trend for overall activity was noted in a univariate analysis, but the association was no longer significant after BMI correction. It was not likely that horizontal pleiotropy, heterogeneity, or individual single-nucleotide polymorphism effects would confound the results obtained for moderate\/vigorous PA.<\/p>\n “Moderate\/vigorous self-reported PA seems to increase schizophrenia risk, results that are difficult to align with current evidence,” the authors write.<\/p>\n Two authors disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n