Increases in glucose, insulin, GLP-1, PYY less robust with sucrose versus glucose ingestion; increases in glucose, PYY smaller in obese adults<\/p>\n<\/h3>\n
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WEDNESDAY, Dec. 30, 2020 (HealthDay News) — Sucrose seems to be less efficient than glucose for signaling postprandial satiation, according to a study published online Dec. 10 in the Journal of Clinical Endocrinology & Metabolism<\/em>.<\/em><\/p>\n Alexandra G. Yunker, from the University of Southern California in Los Angeles, and colleagues examined how oral sucrose versus glucose impacted appetite-regulating hormones among 69 adults. Participants consumed 300-mL drinks containing 75 g of glucose or sucrose on two occasions. At baseline and 10, 35, and 120 minutes after the drink, blood was sampled for plasma glucose, insulin, glucagon-like peptide (GLP-1), peptide YY (PYY), and acyl-ghrelin measures.<\/p>\n The researchers observed a less robust rise in glucose, insulin, GLP-1, and PYY with sucrose versus glucose ingestion, but acyl-ghrelin suppression was similar. There were interactions noted between body mass index status and sugar for glucose and PYY; after consuming sucrose versus glucose, obese individuals had smaller increases in glucose and PYY levels. Interactions were seen between insulin sensitivity and sugar for glucose and insulin, and for GLP-1, there was an interaction between sex and sugar, with a smaller increase in GLP-1 for men in response to sucrose versus glucose.<\/p>\n “These findings highlight the importance of considering individual characteristics that may affect the metabolic consequences of consumption of specific nutrients, such as different types of sugar,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n