Significant increase in glioma risk seen for those with higher antibody titers to the sag-1 antigen<\/p>\n<\/h3>\n
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TUESDAY, Jan. 12, 2021 (HealthDay News) — Some evidence suggests that there is an increased risk for glioma among individuals who have had Toxoplasma gondii <\/em>infection, according to a study published online Jan. 11 in the International Journal of Cancer<\/em>.<\/p>\n James M. Hodge, J.D., M.P.H., from the American Cancer Society in Atlanta, and colleagues examined the association between prediagnostic T. gondii<\/em> antibodies and the risk for glioma in two prospective cohorts. A total of 37 cases and 74 matched controls were selected from the American Cancer Society Cancer Prevention Study-II Nutrition Cohort (CPSII-NC), and 323 cases and 323 controls were included from the Norwegian Cancer Registry Janus Serum Bank (Janus).<\/p>\n The researchers observed an increased glioma risk among those infected with T. gondii<\/em> (odds ratio, 2.70 [95 percent confidence interval, 0.96 to 7.62] for CPSII-NC; odds ratio, 1.32 [95 percent confidence interval, 0.85 to 2.07] for Janus). The increased risk was more prominent in individuals with higher antibody titers to the sag-1 antigen (CPSII-NC odds ratio, 3.35 [95 percent confidence interval, 0.99 to 11.38]; Janus odds ratio, 1.79 [95 percent confidence interval, 1.02 to 3.14]).<\/p>\n “The findings do suggest that individuals with higher exposure to the T. gondii <\/em>parasite are more likely to go on to develop glioma,” a coauthor said in a statement. “However, it should be noted that the absolute risk of being diagnosed with a glioma remains low, and these findings need to be replicated in a larger and more diverse group of individuals.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n