Reaction occurred at or near injection site; reactions were pruritic, painful, and edematous pink plaques<\/p>\n<\/h3>\n
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WEDNESDAY, May 12, 2021 (HealthDay News) — Localized injection-site reactions to the Moderna COVID-19 vaccine reported in 16 patients appear to be delayed hypersensitivity reactions, according to a study published online May 12 in JAMA Dermatology<\/em>.<\/p>\n Margaret S. Johnston, M.D., from the Yale University School of Medicine in New Haven, Connecticut, and colleagues describe the course of localized cutaneous injection-site reactions to the Moderna COVID-19 vaccine in a retrospective case series study. Sixteen patients were referred with localized cutaneous injection-site reactions from Jan. 20 through Feb. 12, 2021.<\/p>\n The researchers found that 14 of the patients self-identified as White and two as Asian. The delayed localized cutaneous reactions developed at a median of seven days after receipt of the Moderna vaccine. These reactions occurred at or near the injection site; they were pruritic, painful, and edematous pink plaques. A mild predominantly perivascular mixed infiltrate with lymphocytes and eosinophils was identified on a skin biopsy specimen, which was consistent with a dermal hypersensitivity reaction. Of the 15 patients who had a reaction to the first vaccine dose, 11 developed a similar reaction to the second vaccine dose; 10 of these patients developed the second reaction sooner than they developed the reaction to the first dose.<\/p>\n “In contrast to immediate hypersensitivity reactions (e.g., anaphylaxis and urticaria) that present within four hours of vaccine administration, these delayed localized hypersensitivity reactions are not a contraindication to subsequent vaccination,” the authors write.<\/p>\n One author disclosed financial ties to Johnson & Johnson.<\/p>\n