Autoimmune progesterone dermatitis (APD) is a rare skin disorder with varying presentations, resulting from hypersensitivity to endogenous progesterone during the luteal phase of the menstrual cycle. The diagnosis has been …
Is apremilast for psoriasis as effective and safe as reported in clinical trials? Five-year experience from a Greek tertiary hospital.
Apremilast was approved as an effective and safe treatment for psoriasis, but clinical trial results may differ from real-life data. This retrospective cross-sectional study evaluated the long-term efficacy and safety …
Laryngeal mucous membrane pemphigoid serves as a prognostic factor for poor response to treatment with rituximab.
Mucous Membrane Pemphigoid (MMP) comprises a group of auto-antibody mediated subepidermal bullous diseases characterized by predominant involvement of mucous membranes and a tendency to scarring. Rituximab (RTX) has emerged as a …
Potential Predictive Biomarkers of Adalimumab Response in Patients with Hidradenitis Suppurativa.
Adalimumab provides significant efficacy for patients with hidradenitis suppurativa (HS) as demonstrated by at least 50% of patients achieving HS clinical response by week 12 that is maintained through week …
Screening May Improve Early Detection for Melanoma-Prone
Reduced thickness of melanoma lesions seen for patients receiving routine skin cancer screening, education about self-exam
Mobile Robotic System Perceived as Acceptable for Health Tasks
Survey suggests robotic system perceived as useful; patients report satisfaction with triage interview using mobile robotic system
Delayed immune-related adverse events with anti-PD1-based immunotherapy in melanoma.
IrAEs typically occur within 4 months of starting anti-PD1-based therapy (anti-PD1 +/- anti-CTLA4), but delayed irAEs (onset >12 months after commencement) can also occur. This study describes the incidence, nature …
Prevalence and incidence of palmoplantar pustulosis in Sweden: a population-based register study.
Palmoplantaris pustulosis (PPP) is a chronic relapsing skin condition characterized by sterile pustules on the palm and soles. Population-based estimates of PPP incidence and prevalence are limited.To estimate the prevalence …
Signaling of multiple IL-17 family cytokines through IL-17RA drive psoriasis-related inflammatory pathways.
The IL-23/IL-17 immune axis is of central importance in psoriasis. However, the impact of IL-17 family cytokines other than IL-17A in psoriasis has not been fully established.To elucidate the contribution …
Ca2+ signalling is critical for autoantibody-induced blistering of human epidermis in pemphigus.
Pemphigus is a severe bullous autoimmune skin disease. Pemphigus foliaceus (PF) is characterized by anti-desmoglein(DSG)-1-IgG causing epidermal blistering, mucosal pemphigus vulgaris (mPV) by anti-DSG-3-IgG inducing erosions in the mucosa, and …