Psoriatic arthritis appears in one in four skin psoriasis patients. Early detection of the presence of joint involvement and early interception of its developments may minimize long-term functional disability, and the …
Metformin is associated with decreased risk of basal cell carcinoma: A whole-population case-control study from Iceland.
Metformin has anti-carcinogenic properties and is also known to inhibit the Sonic hedgehog pathway, but no population-based studies exist analyzing the potential protective effect for basal cell carcinoma (BCC) and …
Phenotypes and therapeutic responses in cutaneous-predominant sarcoidosis
Sarcoidosis is a chronic, multi-system disease characterized by non-necrotizing epithelioid granulomatous inflammation. Organ systems affected include the skin, respiratory tract, ocular, hepatobiliary, renal, cardiac, endocrine, neurological and musculoskeletal tissues [1, …
Invasive and In-Situ Squamous Cell Carcinoma of the Skin: A Nationwide Study in Iceland.
Squamous cell carcinoma (cSCC) incidence is increasing.To evaluate the tumor burden of in-situ and invasive cSCC in Iceland, whose population is exposed to limited UV radiation.This whole population study used …
Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group.
Case-control studies report a dose-dependent increased risk of skin cancer in users of hydrochlorothiazide (HCTZ) vs non-users. The degree to which other thiazides and thiazide-like diuretics (TZs) are associated with …
The status and outcomes of registered clinical trials for JAK inhibitors in alopecia areata: are non-published trials being overlooked?
Recent meta-analyses of Janus kinase (JAK) inhibitors in alopecia areata (AA) have excluded trial registries and may thus be subject to publication bias. This study assessed the potential for evidence …
Risk of liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis receiving methotrexate: a population-based study.
Patients with psoriatic disease may be more susceptible to methotrexate hepatotoxicity than those with rheumatoid arthritis (RA) but direct evidence is lacking.To compare liver disease risk among patients with psoriasis …
Hydroxychloroquine-induced acute generalized exanthematous pustulosis: a series of seven patients and review of the literature.
Hydroxychloroquine (HCQ)-induced acute generalized exanthematous pustulosis (AGEP) is poorly described in the literature. The aim of our study was to characterize the clinical, laboratory, allergological, and genetic features of HCQ-induced …
The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study.
EPHB4 and its ligand, ephrin B2, which are receptor tyrosine kinases of the erythropoietin-producing hepatocellular (EPH) family, are known to be linked to several human cancers. The aim of this …
Baricitinib in patients with moderate-to-severe atopic dermatitis: Results from a randomized monotherapy Phase 3 trial in the United States and Canada (BREEZE-AD5).
Baricitinib, an oral, selective Janus kinase (JAK)1/JAK2 inhibitor, is being studied for moderate-to-severe atopic dermatitis (AD) in adults.To evaluate the efficacy and safety of baricitinib monotherapy in a North American …