Mastocytosis is a heterogeneous group of myeloproliferative disorders characterized by accumulation of clonal mast cells in various tissues. The aim of this study was to determine the symptoms evolution and …
Multifaceted array-based keloidal gene expression profiling reveals specific MDFI upregulation in keloid lesions.
Keloid lesions are characterized by mesenchymal cell proliferation and excessive extracellular matrix deposition. Previous microarray analyses have been performed to investigate the mechanism of keloid development. However, the molecular pathology …
Onychoscopy in a Colombian population with toenail onychomycosis diagnosis: an evaluating diagnostic test study.
Onychomycosis is defined as the infection of nails caused by dermatophytes, yeasts, and non-dermatophyte molds. Fungal infections of the nail represent about 30% of all mycotic cutaneous infections1 and approximately …
A review of Nigella sativa plant-based therapy in dermatology.
Nigella sativa (N. sativa) is a widely used medicinal herb with a rich cultural and religious history in Unani, Ayurveda, Chinese, and Arabic medicine. N. sativa contains many natural bioactive …
Drop in biological initiation for patients with psoriasis during the COVID-pandemic.
Biologics have become the backbone of chronic inflammatory diseases treatment, including psoriasis. Post-approval studies allowed to better understand their safety profile demonstrating a favorable risk-benefit ratio despite an increased risk …
Atopic diseases in children and adolescents are associated with behavioural difficulties.
Atopic diseases and behavioural difficulties in children have both been on the rise in recent decades. This study seeks to assess associations between atopic diseases and behavioural difficulties, examining the …
Real-world experience on off-label use of imiquimod 5% as an adjuvant therapy after surgery or as a monotherapy for lentigo maligna.
Because of the tendency of lentigo maligna (LM) for subclinical extension, staged excisions with margin control achieve lower recurrence rates than conventional wide local excision (0-9.5% vs 8-20%). However, these …
Complete response in a patient with advanced melanoma following anti-PD-1 therapy is associated with high frequency of melanoma-infiltrating CXCR3+ resident memory CD8+ T cells and multiple chemokine pathways.
The use of immune checkpoint inhibitors (ICI), such as anti-programmed cell death-1 (PD-1) antibodies, has profoundly changed melanoma prognosis. However, only 35% to 45% of patients experience durable responses, highlighting …
Bimekizumab versus Secukinumab in Plaque Psoriasis.
Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F. The efficacy and safety of bimekizumab as compared with secukinumab, which selectively inhibits interleukin-17A alone, in patients …
Bimekizumab versus Adalimumab in Plaque Psoriasis.
Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits interleukin-17A and interleukin-17F. The efficacy and safety of bimekizumab as compared with the tumor necrosis factor inhibitor adalimumab in patients with …