Microneedling as an adjuvant to topical medications has shown promising but variable results in the treatment of melasma.To conduct a systematic review and meta-analysis on the efficacy of topical therapy …
Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial.
The European Organisation for Research and Treatment of Cancer (EORTC) 1325/KEYNOTE-054 trial assessed pembrolizumab versus placebo in patients with resected high-risk stage III melanoma. At 15-month median follow-up, pembrolizumab improved …
Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial.
The European Organisation for Research and Treatment of Cancer (EORTC) 1325-MG/KEYNOTE-054 trial in patients with resected, high-risk stage III melanoma demonstrated improved recurrence-free survival with adjuvant pembrolizumab compared with placebo …
In-Vitro Diagnostics for the Medical Dermatologist: Part 2: Hypercoagulability Tests.
The skin often provides initial clues of hypercoagulability with features such as livedo reticularis and racemosa, retiform purpura, necrosis and ulcerations. As these cutaneous manifestations are nonspecific, laboratory testing is …
United States Burden of Melanoma and Non-Melanoma Skin Cancer from 1990 to 2019.
Skin cancer is the most common cancer worldwide.To evaluate burden of skin cancer in the US from 1990 to 2019.Age-standardized incidence, prevalence, disability adjusted life years (DALY) and mortality rates …
Evaluation of the dermatoscopic criteria for the early detection of SCC arising on an AK.
Advanced squamous cell carcinoma (SCC) can easily be discriminated from actinic keratosis (AK), based on clinical and dermatoscopic features. However, at the initial stage of dermal invasion, an SCC might …
In-Vitro Diagnostics for the Medical Dermatologist: Part 1: Autoimmune Tests.
Despite the expansion of available in-vitro laboratory tests at a rate far exceeding that of dermatological pharmaceuticals, the existing literature is dominated by discussion of the latter. With the advent …
Unilateral clubbing-like digital thickening as a clinical manifestation of low-flow vascular malformations: a series of 13 cases.
Digital clubbing is a well-known clinical sign characterized by thickening of the distal phalanges of the fingers and toes. Unilateral clubbing occurs less frequently. A previous report showed for the …
Comparison between cutaneous leishmaniasis patients with facial and non-facial lesions.
We compared demographic, clinical, treatment, and outcome characteristics of facial cutaneous leishmaniasis (CL) and non-facial CL.In this retrospective cohort study, polymerase chain reaction confirmed Leishmania major CL patients with ≥2 …
Stevens-Johnson syndrome and toxic epidermal necrolysis in a referral center in Taiwan.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal adverse drug reactions. The characteristics of these diseases are changing with the use of novel drugs, posing new challenges …