Growing evidence suggests that atopic dermatitis (AD) is associated with an increased risk of depressive disorders and anxiety. However, existing studies were observational and may uncover correlations but cannot easily …
Dermatofibrosarcoma protuberans in pregnancy: a case series and review of the literature.
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma, which has been reported in pregnancy. This case series reports the clinical and histopathological findings of DFSP in pregnancy.Eighteen cases of DFSP, …
Histopathologic upgrading of cutaneous squamous cell carcinomas during Mohs micrographic surgery: A retrospective cohort study.
Initial biopsies of cutaneous squamous cell carcinomas (cSCC) may not reveal aggressive histologic features, which would otherwise inform appropriate surgical management and patient education.To assess the incidence of and risk …
Is apremilast for psoriasis as effective and safe as reported in clinical trials? Five-year experience from a Greek tertiary hospital.
Apremilast was approved as an effective and safe treatment for psoriasis, but clinical trial results may differ from real-life data. This retrospective cross-sectional study evaluated the long-term efficacy and safety …
Intradermal testing for autoimmune progesterone dermatitis: should we be basing our diagnosis on it?
Autoimmune progesterone dermatitis (APD) is a rare skin disorder with varying presentations, resulting from hypersensitivity to endogenous progesterone during the luteal phase of the menstrual cycle. The diagnosis has been …
A clinical review and history of pubic lice.
The ectoparasite, Pthirus pubis (PtP), (crab or pubic louse) has plagued primates from pre-historic apes to Homo sapiens. We combed the literature from antiquity to present day using Medline and …
Laryngeal mucous membrane pemphigoid serves as a prognostic factor for poor response to treatment with rituximab.
Mucous Membrane Pemphigoid (MMP) comprises a group of auto-antibody mediated subepidermal bullous diseases characterized by predominant involvement of mucous membranes and a tendency to scarring. Rituximab (RTX) has emerged as a …
Potential Predictive Biomarkers of Adalimumab Response in Patients with Hidradenitis Suppurativa.
Adalimumab provides significant efficacy for patients with hidradenitis suppurativa (HS) as demonstrated by at least 50% of patients achieving HS clinical response by week 12 that is maintained through week …
Delayed immune-related adverse events with anti-PD1-based immunotherapy in melanoma.
IrAEs typically occur within 4 months of starting anti-PD1-based therapy (anti-PD1 +/- anti-CTLA4), but delayed irAEs (onset >12 months after commencement) can also occur. This study describes the incidence, nature …
Signaling of multiple IL-17 family cytokines through IL-17RA drive psoriasis-related inflammatory pathways.
The IL-23/IL-17 immune axis is of central importance in psoriasis. However, the impact of IL-17 family cytokines other than IL-17A in psoriasis has not been fully established.To elucidate the contribution …