Poikiloderma is a skin condition that combines atrophy, telangiectasia, and macular pigment changes (hypo- as well as hyperpigmentation). It is often mistaken for mottled pigmentation by general practitioners or nondermatology …
Managing pain associated with dermatologic procedures.
Dermatologists are faced with an aging population, accompanied by an increase in the incidence of skin cancer, especially nonmelanoma skin cancer. With this increase in cutaneous malignancy comes an increase …
Mycophenolate mofetil as adjunctive therapy to corticosteroids for the treatment of pyoderma gangrenosum: a case series and literature review.
Pyoderma gangrenosum is a rare neutrophilic dermatosis that is commonly treated with systemic corticosteroids; however, their potent side effects may warrant tapering, and non-steroidal systemic immunosuppressants may help maintain or …
Oral corticosteroid bursts and severe adverse events: a critical appraisal.
Short-term corticosteroids are commonly used to treat various dermatoses. Previous study has indicated oral corticosteroids < 30 days duration increased the risk of gastrointestinal (GI) bleedings, fractures, venous thromboembolism and sepsis.1 …
High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types.
High tumor mutation burden (TMB-H) has been proposed as a predictive biomarker for response to immune checkpoint blockade (ICB), largely due to the potential for tumor mutations to generate immunogenic …
The cardiovascular safety of oral alitretinoin. A population-based cohort study involving 19,513 patients exposed to oral alitretinoin.
Oral alitretinoin is a retinoid used for severe chronic hand eczema. Although caution is recommended for patients with uncontrolled dyslipidaemia or cardiovascular risk factors, the actual atherothrombotic risk has not …
Effect of Dermatologic Consultation on Survival in Patients with Checkpoint Inhibitor Associated Cutaneous Toxicity.
Cutaneous immune-related adverse events (cirAEs) are a common side effect of immune checkpoint inhibitors. However, prior work examining these toxicities in detail has considered only the fraction of events evaluated …
Host traits, lifestyle and environment are associated with the human skin bacteria.
The human skin offers diverse ecosystems for microbial symbionts. However, the factors shaping skin-microbiome interactions are still insufficiently characterized. This contrasts to the broader knowledge about the factors influencing the …
Inflammatory Skin Diseases and the Risk of Chronic Kidney Disease – Population-Based Case-control and Cohort analyses.
Emerging evidence suggests an association between common inflammatory skin diseases and chronic kidney disease (CKD).To explore the association between CKD stages 3-5 and atopic eczema, psoriasis, rosacea, and hidradenitis suppurativa.We …
Oral mini-pulse therapy in vitiligo: a systematic review.
There is limited evidence supporting the use of alternative treatments for patients with nonstable vitiligo.This study aimed to review the effects of oral mini-pulse (OMP) therapy in the management of …