Pyoderma gangrenosum (PG) is an autoinflammatory neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers. Anakinra is a recombinant interleukin-1 (IL-1) receptor antagonist that blocks the activity of IL-1α and IL-1β …
Scalp dysesthesia and lichen simplex chronicus: diagnostic and therapeutic update with literature review.
Scalp dysesthesia and lichen simplex chronicus, conditions that can be associated, are both challenging and frustrating for the patient and the physician. The etiology is not well elucidated and treatment …
Multicentric EORTC retrospective study shows efficacy of Brentuximab Vedotin in Μycosis Fungoides and Sezary Syndrome patients with variable CD30 positivity.
Brentuximab Vedotin (BV) was approved as therapy for Mycosis Fungoides (MF) based on ALCANZA trial. Since then few real-life data are available.The aim of this study was to evaluate efficacy …
Alcohol abuse associated with poor response to systemic therapies for psoriasis: findings from a prospective multicentre cohort study.
Factors that might influence response to systemic treatment for moderate-to-severe psoriasis are varied, and generally, are poorly understood, aside from high body weight, suggesting that other unidentified factors may be …
Development and preliminary validation of the patient-reported Chronic Itch Burden Scale, assessing health-related quality of life in chronic pruritus.
Chronic pruritus (CP) significantly affects patients’ health-related quality of life (HRQoL). Very few self-reported HRQoL questionnaires exploring CP were developed according to international guidelines thus limiting their use in pre-authorization …
Oral isotretinoin: 29 years of medical malpractice cases in the United States.
Reviews of malpractice claims in the United States show trends of increasing payments with statistically higher payouts for more debilitating and permanent injuries.To examine lawsuits involving notable associated adverse reactions …
Management of inadequate response and adverse effects to dupilumab in atopic dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, skin-pain, and sleep disturbances. Currently, dupilumab is the only U.S. FDA approved systemic therapy and biologic medication for …
The Completeness and Accuracy of DataDerm™: The Database of The American Academy of Dermatology (AAD).
The utility of any database or registry depends on the completeness and accuracy of the data it contains. This report documents the validity of data elements within DataDerm, the clinical …
Adverse Pregnancy and Maternal Outcomes in Women with Hidradenitis Suppurativa.
Hidradenitis suppurativa (HS) disproportionately affects women of childbearing age. However, pregnancy and maternal outcomes for women with HS are unknown.To compare risk of adverse pregnancy and maternal outcomes among women …
Delgocitinib ointment in pediatric patients with atopic dermatitis: a phase 3, randomized, double-blind, vehicle-controlled study and a subsequent open-label, long-term study.
Delgocitinib 0.5% ointment, a topical JAK inhibitor, has been approved for adult patients with atopic dermatitis (AD) in Japan.To evaluate the efficacy and safety of delgocitinib ointment in pediatric patients …