During the SARS-CoV-2 pandemic, an outbreak of children with yellow-to-brown pigmentation on the skin was observed. Because of the restrictions on movements promulgated during the lockdown, most consultancies were performed …
Diagnosis of latent tuberculosis infection among pediatric household contacts of Iranian tuberculosis cases using tuberculin skin test, IFN- γ release assay and IFN-γ-induced protein-10.
Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB …
Melanoma mortality in Spain: predictions up to 2043.
Melanoma mortality rates are stabilizing and in certain regions and age groups are trending down. Although there are some studies that predict melanoma mortality in other countries, there are currently …
The stratum corneum water content and natural moisturization factor composition evolve with age and depend on body site.
The study objective was to examine if age and chronic environmental exposure affect the water content and the composition of the natural moisturizing factors (NMFs) of the stratum corneum (SC).Forty …
Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis.
The tubulin polymerization and Src kinase signaling inhibitor tirbanibulin is being investigated as a topical treatment for actinic keratosis, a precursor of squamous-cell carcinoma.In two identically designed double-blind trials, we …
Risk of macrophage activation syndrome in adult-onset Still’s disease patients with skin involvement: A retrospective cohort study.
Small case series and case reports indicated atypical persistent pruritic eruptions (PPEs), another type of skin lesions in adult-onset Still’s disease (AOSD), imply a worse prognosis than typical evanescent rashes.To …
Simvastatin in vitiligo: an update with recent review of the literature.
Patients with vitiligo often seek medical attention, as it diminishes their quality of life resulting in significant morbidity. Several topical and systemic therapies are in vogue targeting the immunological aspect …
Association of the Affordable Care Act’s Medicaid Expansion with the diagnosis and treatment of clinically localized melanoma: A National Cancer Database Study.
The Affordable Care Act’s Medicaid expansion is associated with earlier diagnosis and improved care among lower socioeconomic status populations with cancer, but its impact on melanoma is undefined.To determine the …
How prevalent are financial conflicts of interest in dermatology randomised controlled trials? A cross-sectional study.
Several countries have introduced transparency databases since the last assessment of conflicts of interest (COIs) in dermatology randomised controlled trials (RCTs) in 2004. We assessed the prevalence of financial COIs …
Downregulation of SHANK-associated RH domain-interacting protein elevates interleukin-33 expression by stimulating the Janus kinase 2/signal transducer and activator of transcription signaling pathway in HaCaT cells.
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which T-helper type 2 (Th2 ) immune responses are dominant. SHANK-associated RH domain interacting protein (SHARPIN) is expressed at low levels …