There is wide variation both locally and nationally with respect to the provision of out-of-hours dermatology. Few centres now offer a 24 hour a day service 7 days per week1,2 …
Facial and neck erythema associated with dupilumab treatment: A systematic review.
Dupilumab-associated facial and/or neck erythema was not reported in phase 3 clinical trials for the treatment of atopic dermatitis, but there have been a number of reports of patients developing …
Acne vulgaris: role of the immune system.
Acne vulgaris is a worldwide condition that has a complex pathophysiology. The knowledge of this pathology is clear in its four classic principles based on the pilosebaceous unit; there exists …
Trim21 promotes inflammation in keratinocytes of psoriatic patients.
Psoriasis is a skin disease that manifests as itchy, scaly plaques (patches) on the skin. It is associated with both a physical and psychological burden, and affects 0.5-1% of children …
Cannabinoids in Dermatologic Surgery.
Though known as a medicinal herb for centuries, the recent legalization of cannabinoids across many states has ushered in a new era where cannabinoids have become a popular treatment option …
Biologic Treatment Outcomes in Mucous Membrane Pemphigoid: A Systematic Review.
Mucous membrane pemphigoid (MMP) is an autoimmune disease, which can lead to fibrosis of mucous membranes and functional impairment. Biologic agents should be explored as alternative treatment options to improve …
Differential Profiles of Gamma-Secretase-Notch Signaling in Hidradenitis Suppurativa: The Need for Genotype-Endotype-Phenotype Analysis.
Hidradenitis Suppurativa (HS) is a chronic inflammatory dermatosis in which a subset of patients display genetic variants in components of the gamma secretase complex1 proposed to result in dysregulation of …
Classification of lower extremity venous malformations and risk of knee involvement: A retrospective cohort study.
Venous malformations (VM) are the most common vascular anomaly in the lower extremity. VM can be classified as focal, multifocal or diffuse types. Intraarticular VM (IA-VM) of the knee portends …
Cellulitis in chronic oedema of the lower leg: an international cross-sectional study.
Cellulitis and chronic oedema are common conditions with considerable morbidity. The number of studies designed to assess the epidemiology of cellulitis in chronic oedema are scarce.To investigate the prevalence and …
Beclin1 in Psoriasis: An Immunohistochemical Study.
Abnormal autophagy is now established to be associated with pathogenesis of some skin disorders. Beclin1 plays a central role in the machinery of the autophagy.to assess the expression of “Beclin1” …