Human skin is constantly exposed to solar ultraviolet radiation (UVR). Skin has a unique ability to respond to UVR by increasing its pigmentation, a protective process driven by the melanogenesis …
Modular gene analysis reveals distinct molecular signatures for cutaneous lupus patient subsets.
Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune disease with clinical sequelae such as itching, dyspigmentation, and scarring.We applied a previously described modular analysis approach to assess the molecular heterogeneity …
Image guided lymph node core needle biopsy predicts survival in mycosis fungoides and Sézary syndrome.
The prognosis of Sézary syndrome (SS) and mycosis fungoides (MF) depends on lymph node (LN) involvement. The usefulness of LN image guided core needle biopsies (CNB), instead of surgical sampling, …
Activity and components of the G-CSF pathway in hidradenitis suppurativa.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease, characterized by painful, purulent, and destructive skin alterations in intertriginous areas.We investigated the expression and role of granulocyte-colony-stimulating factor (G-CSF), the regulator …
Subcutaneous abscess caused by Streptococcus pneumoniae serotype 28F in an infant: a case report.
Invasive pneumococcal disease (IPD) is defined by the detection of Streptococcus pneumoniae on culture from samples obtained from a normally sterile site. Pneumococcal conjugate vaccines (PCV) have been developed for …
CERKL is upregulated in cutaneous squamous cell carcinoma and maintains cellular sphingolipids and resistance to oxidative stress.
Ceramide kinase-like protein (CERKL) was originally described in retinal tissue. CERKL has been shown to protect cells from oxidative stress, and mutations in CERKL underlie the inherited disease retinitis pigmentosa. …
Cutaneous immune-related adverse events in patients with melanoma treated with checkpoint inhibitors.
Checkpoint inhibitor (CPI) therapy has vastly improved long-term outcomes in metastatic malignant melanoma (MMM). Therapy takes the form of monoclonal antibody infusions that target immune cell checkpoint proteins, such as …
Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.
The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema (AE) clinical trials. Previous consensus meetings have agreed on preferred instruments …
Scabies involving palms in older children and adults: a changing scenario.
Scabies is a highly contagious, intensely pruritic skin infestation caused by Sarcoptes scabiei var hominis. It has high prevalence in many tropical countries where crowded people live in resource-poor settings. …
Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections.
Neonatal herpes simplex virus (HSV) infection is a devastating disease with high mortality, particularly when disseminated. Studies in adults and children suggest that susceptibility to herpes simplex encephalitis (HSE) may …