While superficial spreading melanomas (SSM) are diagnosed as thinner lesions, nodular melanomas (NM) have a more rapid growth rate and are biologically more aggressive compared to other histologic subtypes.To determine …
Long-term efficacy and safety of ixekizumab: 5-year analysis of the UNCOVER-3 randomized controlled trial.
To report efficacy and safety of the approved IXE dose over 5 years from UNCOVER-3. (NCT01646177).Patients (N=1346) were randomized 1:2:2:2 to receive subcutaneous injections of placebo, etanercept 50 mg twice …
Narrow resection margins are not associated with mortality or recurrence in patients with Merkel cell carcinoma: a retrospective study.
Wide local excision constitutes the standard of care for Merkel cell carcinoma, but the optimal margin width remains controversial.To assess whether narrow margins (0.5 – 1 cm) were associated with …
Morphea patients with mucocutaneous involvement: A cross sectional study from the Morphea in Adults and Children (MAC) cohort.
Demographic and clinical findings of patients with mucocutaneous morphea have not been well characterized.To determine the demographic and clinical characteristics of morphea patients with mucocutaneous lesions enrolled in the Morphea …
Primary cutaneous malignancies in nonalbino and albino Africans.
The pigmented skin of black Africans has been credited with reduction in risk of skin cancer. African albinos have inherited defects in skin melanin deposition, which predisposes them to ultraviolet …
Case reports and narrative fallacies: the enigma of black swans in dermatology.
Narrative fallacy is a problematic heuristic that leads us to make inaccurate cause-effect relationships. They are a particular issue in case reports because of the limited scope of these papers, …
Hidradenitis suppurativa is associated with hypothyroidism and hyperthyroidism: a large-scale population-based study.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving the skin bearing apocrine glands. There are numerous comorbidities and associated diseases among patients with HS. The association of HS and …
Development of an international core domain set for medium, large and giant congenital melanocytic nevi as a first step towards a core outcome set for clinical practice and research.
Medium, large and giant congenital melanocytic nevi (CMN) can impose a psychosocial burden on patients and families, and are associated with increased risk of developing melanoma or neurological symptoms. Lack …
Development of a Core Outcome Set for Cutaneous Squamous Cell Carcinoma Trials: Identification of Core Domains and Outcomes.
The lack of uniformity in the outcomes reported in clinical studies of the treatment of cutaneous squamous cell carcinoma (cSCC) complicates efforts to compare treatment effectiveness across trials.To develop a …
Burden, risk factors and infectious complications of cellulitis and erysipelas in United States adults and children in the emergency department setting.
Little is known about the utilization and burden of emergency department (ED) visits for cellulitis/erysipelas in the United States.To determine the prevalence, risk factors, complications and cost of emergency care …