The human infection caused by the novel SARS-CoV-2 is a public health emergency of international concern. Although the disease associated to this virus, named COVID-19, mainly affects the lungs, the …
The importance of assessing blood tumour burden in cutaneous T-cell lymphoma.
Mycosis fungoides (MF) and Sézary syndrome (SS) are the best studied subtypes of cutaneous T-cell lymphoma, and the level of blood tumour burden in patients is important for diagnosis, disease …
Tapinarof in the treatment of psoriasis: A review of the unique mechanism of action of a novel therapeutic AhR modulating agent (TAMA).
Tapinarof, a novel, first-in-class small-molecule topical therapeutic aryl hydrocarbon receptor (AhR) modulating agent (TAMA), is in clinical development for the treatment of psoriasis and atopic dermatitis. The efficacy of tapinarof …
Enhanced expression of ACE2 in psoriatic skin and its upregulation in keratinocytes by interferon-gamma: Implication of inflammatory milieu in skin tropism of SARS-CoV-2.
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a challenging situation globally due to its contagion nature. SARS-CoV-2 enters the host cell by …
Response to “Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic”.
we noted with interest the recent letter by Earnshaw and colleagues documenting decreased skin cancer referrals to their dermatology department and report a similar phenomenon seen in Ireland on a …
British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma 2020.
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of cutaneous squamous cell carcinoma (cSCC). The document aims to: offer an appraisal of all …
Long non-coding RNA MALAT1 suppresses miR-211 to confer protection from UV-mediated DNA damage in vitiligo epidermis by upregulating SIRT1.
The absence of melanocytes poses a challenge for long-term tissue homeostasis in vitiligo. Surprisingly, while individuals with Fitzpatrick phototypes I-II (low melanin content) have a higher incidence of melanoma and …
Environmental Sustainability in Dermatological Surgery.
The health and social care sector have a substantial environmental impact, accounting for 6.3% of England’s carbon footprint 1 . In view of this, clinicians must ensure all aspects of …
Risk of Skin Disorders in Patients with Celiac Disease: A Population-Based Cohort Study.
Although dermatitis herpetiformis is closely associated with celiac disease (CD), data on the relationship between CD and other dermatologic disorders have been mixed. We aimed to quantify the risk of …
Chilblain-like lesions with prominent bullae in a patient with COVID-19.
A 27-year-old patient presented with acral chilblain-like lesions atypical of dermatological presentations appearing in current reports of COVID-19. Prominent bullae had formed on the dorsa of her toes and became …