Onychomycosis is defined as the infection of nails caused by dermatophytes, yeasts, and non-dermatophyte molds. Fungal infections of the nail represent about 30% of all mycotic cutaneous infections1 and approximately …
Complete response in a patient with advanced melanoma following anti-PD-1 therapy is associated with high frequency of melanoma-infiltrating CXCR3+ resident memory CD8+ T cells and multiple chemokine pathways.
The use of immune checkpoint inhibitors (ICI), such as anti-programmed cell death-1 (PD-1) antibodies, has profoundly changed melanoma prognosis. However, only 35% to 45% of patients experience durable responses, highlighting …
Drop in biological initiation for patients with psoriasis during the COVID-pandemic.
Biologics have become the backbone of chronic inflammatory diseases treatment, including psoriasis. Post-approval studies allowed to better understand their safety profile demonstrating a favorable risk-benefit ratio despite an increased risk …
Real-world experience on off-label use of imiquimod 5% as an adjuvant therapy after surgery or as a monotherapy for lentigo maligna.
Because of the tendency of lentigo maligna (LM) for subclinical extension, staged excisions with margin control achieve lower recurrence rates than conventional wide local excision (0-9.5% vs 8-20%). However, these …
Bimekizumab versus Adalimumab in Plaque Psoriasis.
Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits interleukin-17A and interleukin-17F. The efficacy and safety of bimekizumab as compared with the tumor necrosis factor inhibitor adalimumab in patients with …
Bimekizumab versus Secukinumab in Plaque Psoriasis.
Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F. The efficacy and safety of bimekizumab as compared with secukinumab, which selectively inhibits interleukin-17A alone, in patients …
Hidradenitis suppurativa: pathogenesis, clinical presentation, epidemiology, and comorbid associations.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that is clinically defined by lesions ranging from painful, deep seated nodules to abscesses, draining sinus tracts, and ultimately, irreversible fibrotic …
Salt and skin.
The introduction of salt as a therapeutic agent in dermatological disorders has been in use since ancient times. This ubiquitous agent is the most underrated substance after the advent of …
Clinical Impact of Immunotherapy in Merkel Cell Carcinoma patients: A Systematic Review and Meta-Analysis.
Immunotherapy is emerging as an alternative for Merkel cell carcinoma (MCC), but its long-term effects on response, survival, and safety are not well established. High-quality evidence is needed to estimate …
YouTube as a source of educational information for natural hair.
There has been a rise in popularity of natural hair, a movement normalizing afro-textured hair in its natural state, without chemical or heat alteration. It is thought that genetic predisposition …