Tape strips have been used widely in dermatology research as a minimally-invasive method to sample the epidermis, avoiding the need for skin biopsies. Most research has focused on epidermal pathology, …
Total Body Photography for the Diagnosis of Cutaneous Melanoma in Adults: A Systematic Review and Meta-Analysis.
Early detection of melanoma is essential to reduce mortality. Total body photography (TBP) can facilitate the detection of melanoma in high-risk individuals. However, the accuracy of TBP in diagnosing melanoma …
Fludarabine modulates expression of type VII collagen during haematopoietic stem cell transplantation for recessive dystrophic epidermolysis bullosa.
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe, complicated inherited blistering skin disease with few treatment options currently available. Recently, haematopoietic stem cell transplantation (HCT) has been used as an …
Skin Disease is More Recalcitrant Than Muscle Disease: A Long-Term Prospective Study of 184 Children with Juvenile Dermatomyositis.
Persistent skin manifestations, especially calcinoses, contribute to morbidity in children with juvenile dermatomyositis (JDM).To compare the course of skin and muscle involvement and document frequency of calcinosis in JDM.Prospective cohort …
Evaluation of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata: A randomized observer-blinded, placebo-controlled, split-head pilot study.
Platelet-rich plasma (PRP) has shown some promise in the treatment of alopecia areata.To evaluate the effect of PRP on hair regrowth and lesional T-cell cytokine expression in alopecia areata METHODS: …
Association between vitiligo and hearing loss: A systemic review and meta-analysis.
Vitiligo is a common depigmenting disorder caused due to autoimmune destruction of melanocytes. Some evidences suggest the involvement of melanocytes in the auditory system in the disease process. However, the …
Genes and phenotypes in vascular malformations.
Vascular malformations (VMs) are caused by localized defects of vascular development. Most VMs are due to sporadic, postzygotic mutations, while some are the result of autosomal dominant germline mutations. Genotype-phenotype …
Vitiligo: an update on systemic treatments.
Vitiligo is an autoimmune skin condition characterized by depigmented macules and patches, and has a huge psychosocial impact on patients. Treatment of vitiligo aims to prevent the spread of disease …
The Immunopathogenesis and Immunotherapy of Cutaneous T Cell Lymphoma: Part II, Current and Future Approaches.
In the past few decades, immunotherapy has emerged as an effective therapeutic option for patients with cutaneous T cell lymphoma (CTCL). CTCL is characterized by progressive impairment of multiple arms …
The Immunopathogenesis and Immunotherapy of Cutaneous T Cell Lymphoma: Part I, Pathways and Targets for Immune Restoration and Tumor Eradication.
Cutaneous T cell lymphomas (CTCLs) are malignancies of skin-trafficking T cells. Patients with advanced CTCL manifest immune dysfunction that predisposes to infection and suppresses the anti-tumor immune response. Therapies that …