Keloid lesions are characterized by mesenchymal cell proliferation and excessive extracellular matrix deposition. Previous microarray analyses have been performed to investigate the mechanism of keloid development. However, the molecular pathology …
A review of Nigella sativa plant-based therapy in dermatology.
Nigella sativa (N. sativa) is a widely used medicinal herb with a rich cultural and religious history in Unani, Ayurveda, Chinese, and Arabic medicine. N. sativa contains many natural bioactive …
Real-world experience on off-label use of imiquimod 5% as an adjuvant therapy after surgery or as a monotherapy for lentigo maligna.
Because of the tendency of lentigo maligna (LM) for subclinical extension, staged excisions with margin control achieve lower recurrence rates than conventional wide local excision (0-9.5% vs 8-20%). However, these …
Atopic diseases in children and adolescents are associated with behavioural difficulties.
Atopic diseases and behavioural difficulties in children have both been on the rise in recent decades. This study seeks to assess associations between atopic diseases and behavioural difficulties, examining the …
Complete response in a patient with advanced melanoma following anti-PD-1 therapy is associated with high frequency of melanoma-infiltrating CXCR3+ resident memory CD8+ T cells and multiple chemokine pathways.
The use of immune checkpoint inhibitors (ICI), such as anti-programmed cell death-1 (PD-1) antibodies, has profoundly changed melanoma prognosis. However, only 35% to 45% of patients experience durable responses, highlighting …
Drop in biological initiation for patients with psoriasis during the COVID-pandemic.
Biologics have become the backbone of chronic inflammatory diseases treatment, including psoriasis. Post-approval studies allowed to better understand their safety profile demonstrating a favorable risk-benefit ratio despite an increased risk …
Tocilizumab Preserves Lung Function in Early Systemic Sclerosis
Stabilization of lung function independent of the extent of quantitative radiographic interstitial lung disease or fibrosis at baseline
Psoriasis Incidence in the United States Remains Steady
New diagnosis of psoriasis increases with age, is similar between sexes, and is greatest among Whites
Hidradenitis suppurativa: pathogenesis, clinical presentation, epidemiology, and comorbid associations.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that is clinically defined by lesions ranging from painful, deep seated nodules to abscesses, draining sinus tracts, and ultimately, irreversible fibrotic …
Bimekizumab versus Adalimumab in Plaque Psoriasis.
Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits interleukin-17A and interleukin-17F. The efficacy and safety of bimekizumab as compared with the tumor necrosis factor inhibitor adalimumab in patients with …